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Abstract #3904

Default mode networks connectivity characterization in young adults with sickle cell disease using 7T resting functional magnetic resonance imaging

Nadim S Farhat1, Helmet T Karim2, Tales Santini1, Neilesh Vinjamuri1, Howard J Aizenstein1,2, Enrico M Novelli3,4,5, and Tamer S Ibrahim1,6,7

1Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States, 2Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, Pittsburgh, PA, United States, 3Pittsburgh Heart, Lung and Blood Vascular Medicine Institute, University of Pittsburgh school of medicine, Pittsburgh, PA, United States, 4Sickle Cell Center of Excellence, University of Pittsburgh school of medicine, Pittsburgh, PA, United States, 5Division of Hematology/Oncology, University of Pittsburgh school of medicine, Pittsburgh, PA, United States, 6Department of Radiology, University of Pittsburgh, Pittsburgh, PA, United States, 7Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, United States

In this study, we investigated altered resting state default mode network (DMN) connectivity using functional magnetic resonance imaging (rs-fMRI) at 7T in young adults(n=13) with sickle cell disease. The DMN of SCD of young adults had higher connectivity as compared to a healthy controls(n=9 ) gender, age, and racially matched group.

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