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Abstract #3955

Multi-Excitation MRE in Aging Human Brain: Estimation of Direction-Dependent Mechanical Properties

Nicolas R Gallo1, Stacey M Cahoon1, Aaron A Anderson2, Assimina A Pelegri3, and John G Georgiadis1,2

1Biomedical Engineering Department, Illinois Institute of Technology, Chicago, IL, United States, 2Beckman Institute, University of Illinois at Urbana-Champaign, Champaign, IL, United States, 3Department of Mechanical & Aerospace Engineering, Rutgers University, Piscataway, NJ, United States

Healthy aging affects the local mechanical properties of the human brain tissue but their estimation remains a challenge, especially in strongly anisotropic white matter regions. This study merges previous MRE aging research involving high-resolution, full-coverage, and multi-excitation MRE imaging with the ability to estimate anisotropic shear moduli locally. We identified important anisotropic differences in the storage modulus in the corpus callosum, which help differentiate old from the young.

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