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Abstract #3958

Characterization of fibril aggregates in ex vivo rat brain with multi-frequency MR Elastography – Preliminary results

Mathilde Bigot1, Fabien Chauveau2, Ralph Sinkus3, Olivier Beuf1, and Simon Auguste Lambert1

1Univ. Lyon, INSA-Lyon, Université Claude Bernard Lyon 1, UJM-Saint Etienne, CNRS, Inserm, CREATIS UMR 5220, U1206, Lyon, France, 2Univ. Lyon, Lyon Neuroscience Research Center, CNRS UMR 5292, INSERM U1028, Univ. Lyon 1, Lyon, France, 3INSERM U 1148, Laboratory of Vascular Translational Science; X. Bichat Hospital University Paris Diderot, Paris, France

Fibrils are biomarkers for early stages of dementia. In this work, α-synuclein fibrils were injected in rat striatum. Brains were imaged ex-vivo using multi-frequency MR Elastography. Estimation of the real part kr of the complex wave number was made for each studied frequency in ROIs surrounding the inclusion, a contralateral control injection and the whole brain. Exponent of the frequency power law was derived from kr maps acquired at different frequencies. No difference was observed between kr values for the different ROIs, but the exponent was more important at the fibrils location, potentially indicating that multi-frequency MRE can detect fibrils.

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