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Abstract #3970

Effect of breath hold mode on the storage modulus of the liver in healthy individuals studied with a gravitational transducer at magnetic resonance elastography

Philippe Garteiser1, Gwenael Page1, Aimé-Pacifique Manzi2, Valérie Vilgrain2, Ralph Sinkus3,4, and Bernard E Van Beers1,2

1Center for Research on Inflammation, Inserm UMR1149, Paris, France, 2Radiology department, Beaujon hospital, AP-HP, Clichy, France, 3King's College London, London, United Kingdom, 4LVTS, Inserm U1149, Paris, France

Although MR elastography (MRE) is a preferred diagnostic tool for hepatic fibrosis, MRE-derived mechanical properties are affected by factors such as portal pressure. Since portal pressure is modulated across the breathing cycle, we sought to evaluate the effect of breathing condition by acquiring MRE in end expiration and end inspiration in 19 healthy volunteers. A gravitational transducer operating at 50Hz was used, which yielded a satisfactory repeatability. Storage modulus values were significantly higher at end inspiration than at end expiration, and the amplitude of the difference was significantly correlated to the end inspiration storage modulus values.

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