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Abstract #3981

Optimizing Neuromelanin-sensitive Turbo Spin Echo sequences using the extended phase graph formalism including magnetization transfer effects

Rita G. Nunes1,2, Rui P A G Teixeira2, Shaihan J Malik2,3, and Joseph V Hajnal2,3

1ISR-Lisboa/LARSyS and Department of Bioengineering, Instituto Superior T├ęcnico - Universidade de Lisboa, Lisbon, Portugal, 2Centre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, 3Biomedical Engineering Department, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom

Neuromelanin(NM)-sensitive imaging detects contrast differences due to magnetization transfer (MT) effects. We aimed to evaluate the value of adding preparation inversion pulses (IR) to multi-slice turbo spin echo (MS-TSE) sequences, using the recently introduced extended phase graphs with MT effects framework. Simulation results were in agreement with experimental phantom data. The MT contrast could be increased using IR MS-TSE sequences and these results were confirmed in vivo, with improved detectability of the substantia nigra. The next step will be to test the use of this type of sequences in the clinic, finding the optimal tradeoff between contrast and signal-to-noise ratio.

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