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Abstract #3991

Thermal sensitive pH imaging using CEST

Yuki Kanazawa1, Daiki Chiba1, Masafumi Harada1, Tosiaki Miyati2, Mitsuharu Miyoshi3, Hiroaki Hayashi2, Yuki Matsumoto1, Takashi Abe1, and Akihiro Haga1

1Tokushima University, Tokushima, Japan, 2Kanazawa University, Kanazawa, Japan, 3Global MR Applications and Workflow, GE Healthcare Japan, Tokyo, Japan

We performed phantom study with CEST and clarified pH change depending on temperature. Linear regression analysis shows a strong significant correlation between temperature and MTRasym at 2.0 ppm in all egg white albumin samples (R2 > 0.78, P < 0.05). As pH changed with temperature, we found that the offset frequency of MTRasym was more sensitive at 2.0 ppm than that at 3.5 ppm.

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