Abstract #4065

Measurement of Uterine Artery and External Iliac Artery Pulse Wave Velocity using 4D Flow MRI

Eileen Hwuang¹, Nadav Schwartz², Dylan Tisdall³, John Detre^3,4, and Walter Witschey³

¹Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, United States, ²Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, PA, United States, ³Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, ⁴Department of Neurology, University of Pennsylvania, Philadelphia, PA, United States

Maintenance of blood supply to the placenta is believed to be dependent on the geometric and hemodynamic properties of the uteroplacental vasculature. In this study we present an MRI method for measuring pulse wave velocity in the uterine arteries. In 6 healthy pregnant subjects, we measured path length and time-to-peak of the velocity waveforms in the uterine arteries and external iliac arteries. The uterine arteries have lower pulse wave velocity than the external iliac arteries (5.5±2.5 vs. 12.9±4.6 m/s, p=3x10^-5), indicating possible biomechanically greater compliance.

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