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Abstract #4068

Assessment of placental microcirculation by joint analysis of flow compensated and non-flow compensated intravoxel incoherent motion data

Esra Abaci Turk1, Borjan Gagoski1, Jeffrey N. Stout1, S. Mazdak Abulnaga2,3, Natalie Copeland1, Drucilla J. Roberts4, Polina Golland2,3, Lawrence L. Wald5,6,7, Elfar Adalsteinsson2,7,8, William H. Barth Jr9, P. Ellen Grant1, and Yogesh Rathi10

1Fetal-Neonatal Neuroimaging & Developmental Science Center, Boston Children's Hospital, Boston, MA, United States, 2Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, United States, 3Computer Science and Artificial Intelligence Laboratory (CSAIL), Massachusetts Institute of Technology, Cambridge, MA, United States, 4Department of Pathology, Massachusetts General Hospital, Boston, MA, United States, 5Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 6Department of Radiology, Harvard Medical School, Boston, MA, United States, 7Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, United States, 8Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, United States, 9Maternal-Fetal Medicine, Obstetrics and Gynecology, Massachusetts General Hospital, Boston, MA, United States, 10Psychiatry Neuroimaging Laboratory, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, United States

Using diffusion weighted imaging and the intravoxel incoherent motion model (IVIM) of blood flow in capillaries, we can measure placental properties relating to maternal and fetal blood flow and perfusion. In this study, we focused on improving the accuracy and precision of the estimated parameters in IVIM imaging by using joint analysis of flow compensated and non-flow compensated diffusion data. With flow compensation, we observed strong re-phasing, approximately cancelling the blood flow effect and allowing more accurate and consistent estimation of diffusion and perfusion measures.

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