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Abstract #4071

Fetal Brain Tissue Characterization at 1.5 T using STAGE

Feifei Qu1, Taotao Sun2, Yongsheng Chen1,3, Brijesh Kumar Yadav1,4, Ling Jiang2, Zhaoxia Qian2, and Ewart Mark Haacke1,3,4

1Department of Radiology, Wayne State University School of Medicine, DETROIT, MI, United States, 2Department of Radiology, International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China, 3The MRI Institute for Biomedical Research, Bingham Farms, MI, United States, 4Department of Biomedical Engineering, College of Engineering, Wayne State University, DETROIT, MI, United States

MRI-based tissue properties such as T1 and proton spin density are known to be important biomarkers of fetal brain maturation. However, fetal motion poses a big challenge in MRI due to long scan durations. Henceforth, there is lack of knowledge about the MRI properties of the human fetal brain tissue. To address these issues, in this study we use a rapid multiparametric method referred to as Strategically Acquired Gradient Echo (STAGE) imaging to obtain T1 and proton density maps of the fetal brain and generate T1-weighted images with enhanced tissue contrast in two minutes.

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