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Abstract #4136

Comparison of hyperpolarised 3He and 129Xe ventilation MRI to assess lung disease in cystic fibrosis

Laurie J Smith1,2, Guilhem J Collier1, Helen Marshall1, Paul J.C Hughes1, Alberto Biancardi1, Graham Norquay1, Jody Bray1, Oliver Rodgers1, Martin Wildman3, Noreen West2, Alex Horsley4, and Jim Wild1

1POLARIS, Academic Radiology, University of Sheffield, Sheffield, United Kingdom, 2Sheffield Children's Hospital NHS Foundation Trust, Sheffield, United Kingdom, 3Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom, 4Respiratory research group, Division of infection, immunity and respiratory medicine, University of Manchester, Manchester, United Kingdom

Ventilation MRI using hyperpolarised gases is highly sensitive to early cystic fibrosis lung disease. With the recent move towards 129Xe from 3He, we aimed to assess both gases in parallel in patients with CF, at baseline and follow-up, to determine whether any inherent bias was present when assessing lung disease. We found that there was no inherent bias for VDP between the two gases present although at an individual level differences were evident. Despite this, when followed up at a later date both gases similarly reflected changes in ventilation, suggesting both are capable of reflecting CF lung disease severity.

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