Abstract #4138

In vivo Validation of Upper Airway Respiratory Computational Fluid Dynamics (CFD) with Phase-Contrast MRI of Hyperpolarized 129Xe

Alister J Bates¹, Matthew M Willmering², Robert Thomen³, Chamindu Gunatilaka², Md Monir Hossain⁴, Charles Dumoulin⁵, and Jason Woods²

¹Upper Airway Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, ²Center for Pulmonary Imaging Research, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, ³Departments of Bioengineering and Radiology, University of Missouri, Columbia, MO, United States, ⁴Division of Biostatistics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, ⁵Imaging Research Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States

Computational fluid dynamics (CFD) can provide clinicians with otherwise unobtainable information such as regional airway resistance and breathing effort. However, CFD has yet to be validated in vivo and has only been compared to in vitro experiments that do not represent all aspects of airway physiology.

To achieve in vivovalidation, velocities produced by CFD were compared to those measured by phase-contrast MRI of inhaled hyperpolarized ¹²⁹Xe.

Voxelwise comparison of velocities between the two methods produced an R² value of 0.75 and a slope of 0.91. Phase-contrast MRI produces a benchmark that allows validation and optimization of CFD simulations.

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