MR safety evaluations of metallic implants/devices are performed in single homogeneous media. However, most of the implants/devices function in different media interfaces such as DBS and iEEG electrodes, catheters, biopsy needles…, etc. Loading of the conducting lines change drastically inside media with different dielectric properties, so does the RF-induced heating characteristics. To improve in vitro MR safety evaluations, we introduce a new TF measurement setup that allows safety evaluations in cascaded media (CM). The performance of the CM-TF setup was verified on isolated and bare lead wires immersed in air/tissue-simulating-medium interface by comparing to FDTD simulations and analytical models.