Ubiquitous Mitochondrial Creatine Kinase (CKMT1) is a mitochondrial membrane protein that catalyzes the reversible conversion of creatine (Cr) to phosphocreatine (PCr). This study shows that in two triple-negative breast cancer cell lines, CKMT1-overexpression resulted in significant increases in intracellular Cr and PCr and conferred increases in cell viability while decreasing migration, invasion and adhesion. Since CKMT1 has been identified as a prognostic indicator in several cancers, it may play a role in oncogenesis and/or cancer progression. Thus, CKMT1 holds promise as a potential diagnostic marker and/or treatment target whose expression can be monitored using magnetic resonance spectroscopy-detected Cr and PCr levels.
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