Meeting Banner
Abstract #4225

Glucose metabolism in the brain of an Alzheimer mouse model by deuterium MRS

Andor Veltien1, Jack Van Asten1, Tom Peeters1, Maximilian Wiesmann2, Ria De Haas3, Amanda Kiliaan2, and Arend Heerschap1

1Radiology and Nuclear Medicine, Radboud university medical center, Nijmegen, Netherlands, 2Department of Anatomy, Radboud university medical center, Nijmegen, Netherlands, 3Department of Pediatrics of Radboud Center for Mitochondrial Medicine, Radboud university medical center, Nijmegen, Netherlands

In this study we show that Deuterium Magnetic Resonance Spectroscopy (DMRS) of the mouse brain after a bolus application of [6,6’-2H2]glucose is feasible at a high SNR and time resolution. We demonstrate that this can be applied to a transgenic mouse model of Alzheimer disease showing clear differences in the glucose uptake and metabolism with a WT mouse. In Deuterium Metabolic Imaging (DMI) mode this could be an alternative approach for FDG PET in Alzheimer disease.

This abstract and the presentation materials are available to members only; a login is required.

Join Here