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Abstract #4263

Macrocyclic Manganese (II) Complex of Mefenamic acid (MA) Conjugate as an Inflammation Targeting MRI Contrast Agent

Md Kamrul Islam1, Hee-Kyung Kim2,3, Soyeon Kim1, Bo Kyung Sung1, Garam Choi1, Ah Rum Baek1, Sunghwan Hwang1, Byeong Woo Yang1, Heejin Seo1, Hoesu Jung4, Taekwan Lee4, and Yongmin Chang5

1Medical and Biological Engineering, Kyungpook National University, Daegu, Korea, Republic of, 2Molecular Medicine, Kyungpook National University, Daegu, Korea, Republic of, 33Institute of Biomedical Engineering Research, Kyungpook National University, Daegu, Korea, Republic of, 4Laboratory Animal Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, Korea, Republic of, 5Radiology, Kyungpook National University, Daegu, Korea, Republic of

The purpose of the present study is to design and synthesis of novel macrocyclic Mn2+ complex as an alternative to the well-established Gd3+ based chelates for use as an inflammation targeting MR imaging agent. This new complex exhibits higher r1 relaxivity (2.32 mM−1 s−1) than clinically approved Mn-DPDP® (1.6 mM−1 s−1) at 4.7 T. T1-weighted MR coronal images display strong signal enhancement in liver, heart, gallbladder and kidney. In an inflammatory mouse model, it shows greater inflammatory tissues detection with in a clinical dose.

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