The undisputed usefulness in biomedical applications, the high carbon polarization (up to 70%) and the long relaxation time constant have made “neat [1-13C]pyruvic acid plus trityl” the most studied dissolution-DNP sample. Nevertheless, too often results valid for this particular preparation are considered to hold also for other trityl-based samples, limiting the potential of other biologically interesting substrates. In the present study we demonstrate that the sample composition and magnetic field affect the trityl ESR properties. A thorough optimization of the these parameters lead to a dramatic increase of [U-13C]glucose polarization from 37±4% to 69±3%, the highest value reported to date.
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