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Abstract #4295

Apparent metabolic exchange rate mapping using saturation-recovery acquisition and Michaelis-Menten modelling

Rolf F Schulte1, Esben SS Hansen2, Uffe Kjaergaard2, Marion I Menzel1, and Christoffer Laustsen2

1GE Healthcare, Munich, Germany, 2MR Research Centre, Aarhus University, Aarhus, Denmark

Injecting high doses of hyperpolarised 13C pyruvate in vivo leads to saturation effects: more precursor will not increase the amount of downstream substrate, leading to errors when quantifying with the conventional two-site exchange model. Saturation effects can be modelled via a Michaelis-Menten kinetics, however requiring metabolic exchange rates measured at multiple time points as input. In this work we extend a previous saturation-recovery measurement to map apparent metabolic exchange rates taking saturation effects into account.

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