Lung cancer is characterized by high intra-tumoral heterogeneity, which potentially increases the difficulties of obtaining accurate biopsy results. By combining CT guided-biopsy of lung masses with previously acquired PET/MR images, we investigated the pathological statuses and gene mutation of tissues samples from different locations within one tumor. The results demonstrated that PET/MR can increase the accuracy of a biopsy as well as enhance our understanding of the complicated biological behaviors of cancers.
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