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Abstract #4354

Calibrated fMRI as a Complementary Diagnostic Method for Epilepsy

Qikai Qin1,2, Miao Zhang3, Peng Huang4, Wei Liu4, Hongping Meng3, Biao Li3, Bomin Sun4, Mu Lin5, Zheng Wang6, Raymond C. Stevens1,2, and Garth J. Thompson1

1iHuman Institute, ShanghaiTech University, Shanghai, China, 2School of Life Science and Technology, ShanghaiTech University, Shanghai, China, 3Department of Nuclear Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, 4Department of Functional Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, 5MR Collaboration, Siemens Healthcare Ltd., Shanghai, China, 6Institute of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China

Epilepsy, one of the most common neurological disorders, is a chronic and recurrent disorder of the brain characterized by unprovoked seizures. Unfortunately, conventional diagnostic methods are limited due to the difficulties of precise localization of the epileptogentic zone. Here, we introduce the calibrated functional MRI (fMRI) to calculate the oxygen to glucose index (OGI) with a combined PET/MR system. With this approach we were able to observe large decreases in relative OGI within the affected hemisphere of epileptic patients. Our method, if proven to locate epileptic foci better than glucose-PET methods alone, will represent an important new diagnostic tool for epilepsy.

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