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Abstract #4365

Innate immune cell tracking in the glioma microenvironment by correlated magnetic resonance imaging and multi photon microscopy (MR-MPM)

Kianush Karimian-Jazi1,2, Philipp M√ľnch1,3, Allen Alexander1,3, Manuel Piechutta2, Matthia Karreman2, Gergely Solecki2, Anna Sophie Berghoff2, Wolfgang Wick2,4, Sabine Heiland1, Martin Bendszus1, Michael Platten3,5, Frank Winkler2,4, and Michael Oliver Breckwoldt1,3

1Neuroradiology, Neuroradiology Department, University Hospital Heidelberg, Heidelberg, Germany, 2Clinical Cooperation Unit Neurooncology, German Cancer Consortium (DKTK) within the German Cancer Research Center (DKFZ), Heidelberg, Germany, 3Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 4Neurology Clinic and National Center for Tumor Diseases, University Hospital Heidelberg, Heidelberg, Germany, 5Department of Neurology, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany

The tumor microenvironment (TME) plays a key role for tumor biology. Composition of the TME correlates with overall survival and governs therapy response. Non invasive assessment of the TME has been notoriously difficult. We have designed an imaging strategy to non invasively visualize innate immune cell dynamics in the TME by correlated MRI and multiphoton microscopy. This approach allowed us to visualize the single steps of nanoparticle uptake by blood born monocytes that give rise to tumor macrophages in an experimental glioma model. We further found that nanoparticle uptake also occurs via the disrupted blood-brain barrier into the brain parenchyma where NP are taken up by tumor associated microglia.

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