Intravenously injected vitamin C is re-emerging as a potential chemotherapeutic agent but questions remain about its bioavailability and metabolic fate. Using newly developed methods for signal denoising, we show that is possible to image vitamin C pharmacokinetics by non-hyperpolarized 13C MRI with significant sensitivity and time resolution that the accumulation of vitamin C into a tumor and its metabolism into downstream metabolites can be visualized. Since the method does not rely on hyperpolarization and therefore does not have restrictions on T1 relaxation, it can be potentially extended to other highly tolerated drugs.
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