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Abstract #4409

Improving quantification accuracy in whole brain high spatial resolution 3D kinetic mapping: Development of a novel dual temporal resolution DCE-MRI technique

Ka-Loh Li1, Daniel Lewis2, Alan jackson1, Sha Zhao1, and Xiaoping Zhu1

1Division of Informatics, Imaging and Data Sciences, University of Manchester, Manchester, United Kingdom, 2Manchester Centre for Clinical Neurosciences, Salford Royal NHS foundation trust, Manchester Academic Health Science Centre, United Kingdom

Mapping microvascular parameters from DCE MRI traditionally requires a compromise between temporal resolution, spatial resolution, and volume coverage. This study developed a dual-temporal-resolution-based analysis method which concatenates acquired high temporal (HT) and high spatial (HS) tissue contrast agent concentration curves into a unified HTHS merged volume and then pixel-by-pixel reconstructed the HT first pass concentration curve to a HS resolution before undertaking kinetic analysis. In vivo assessment of this method was undertaken in 12 patients with neurofibromatosis type II, and demonstrated the potential of the new method to provide high spatial resolution kinetic map with HT comparable accuracy and quality.

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