Three-dimensional (3D) SPACE (sampling perfection with application optimized contrast using different flip angle evolutions) sequences are the workhorse for volume imaging with isotropic spatial resolution. However, spatial resolution is often scarified to achieve clinically acceptable scan time. Conventional one- and two-dimensional parallel imaging techniques could help reducing the scan time but would lead to deteriorated signal-to-noise (SNR) performance at submillimeter spatial resolutions. In this study, three-dimensional parallel imaging technique-Wave-CAIPI is utilized to improve the SNR performance for whole brain SPACE imaging with isotropic 0.6 mm resolution. In vivo results demonstrated that Wave-CAIPI could improve the SNR at 5x acceleration.