Problem Early detection of high-grade malignancy, such as GBM, remains challenging using MRI.
Methods A new approach using continuous-wave and feedback field to reach “fixed-point spin dynamics” was developed to enhances the local magnetic-field gradient variations due to irregular water contents and deoxyhemoglobin concentration in early GBM.
Results In vivo MR images and mappings acquired on orthotopic GBM mice using “fixed-point pulse sequence” shows 3-4 times of enhancement in GBM contrast than the best conventional images acquired.
Conclusion Simulations and in vivo GBM mouse models validated the superior contrast/sensitivity and robustness of fixed-point spin dynamics method towards early GBM detection.
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