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Abstract #4941

Dynamic quantitative susceptibility mapping to assess vascular compliance in the brain

Christoph Birkl1,2, Christian Langkammer2, Pascal Sati3, Christian Enzinger2, Franz Fazekas2, and Stefan Ropele2

1UBC MRI Research Centre, University of British Columbia, Vancouver, BC, Canada, 2Department of Neurology, Medical University of Graz, Graz, Austria, 3Translational Neuroradiology Unit, Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States

In this study we explored if quantitative susceptibility mapping (QSM) allows assessing blood pressure induced changes of the magnetic susceptibility in the brain as consequence of cerebral autoregulation. Eight healthy subjects underwent fast QSM at 3.0-T and simultaneous measurement of the mean arterial pressure (MAP) following a small drop in MAP caused by a change in posture. A linear relationship between MAP and susceptibility was observed, where the slope represents a measure of the cerebral vascular compliance with different signs for arterial and venous blood vessels.

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