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Abstract #4955

Alternative Slice Acquisition Orders for High-Resolution MB-EPI PCASL Imaging with Background Suppression

Xiufeng Li1, Dingxin Wang1, Gregory J Metzger1, Essa Yacoub1, and Kamil Ugurbil1

1Radiology-Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States

Relative static tissue signal differences between neighboring slices across slice bands in MB-EPI PCASL imaging with background suppression (BS) are dramatically larger than those in MB-EPI PCASL imaging without BS, and can result in severe subtraction errors/artifacts for imaging data with large subject motion that sometimes cannot be corrected or removed by motion correction. To resolve this issue, alternative slice acquisition orders are proposed and evaluated. Our results suggest that the proposed alternative slice acquisition orders can improve the robustness of MB-EPI PCASL imaging with BS, providing comparable CBF estimates with minimized subtraction errors.

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