Velocity-selective arterial spin labeling (VSASL) has the advantage of insensitivity to transit time delay compared to the spatially selective method, thus potentially providing more accurate and robust blood flow measurements in cerebrovascular diseases. Fourier-transform based velocity-selective inversion (FT-VSI) prepared ASL has higher sensitivity to perfusion signal than conventional velocity-selective saturation (VSS) prepared methods. To date, VSASL has largely been implemented with 2D EPI acquisitions. However, a 3D readout is preferred for ASL techniques. This study demonstrated the feasibility of FT-VSI prepared VSASL with 3D whole-brain coverage and compared it with conventional VSS ASL and pseudo-continuous ASL (PCASL) at 3T.
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