Abstract #4986

Characterising the temporal evolution of fixation in human post mortem brain via linear relaxometry modelling – a marker of cross-linking?

Siawoosh Mohammadi^1,2, Sebastian Papazoglou¹, Herbert Mushumba³, Mohammad Ashtarayeh¹, Klaus Püschel³, Gunther Helms⁴, Martina F Callaghan⁵, Nikolaus Weiskopf², and Tobias Streubel^1,2

¹Department of Systems Neuroscience, Medical Center Hamburg-Eppendorf, Hamburg, Germany, ²Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, ³Department of Legal Medicine, Medical Center Hamburg-Eppendorf, Hamburg, Germany, ⁴Department of Clinical Sciences Lund, Lund University, Lund, Sweden, ⁵Wellcome Centre for Human Neuroimaging, UCL Institute of Neurology, London, United Kingdom

MRI-based biophysical models are typically validated by comparison to ex-vivo histology of fixed tissue. The fixation process itself and the accompanied autolysis processes strongly modify tissue composition, and lead to MR signal changes, making the validation of biophysical models for in vivo MRI particularly challenging. To better understand the temporal evolution of the fixation process within the whole brain and its influence on MRI parameters, we monitor the temporal evolution of the fixation process of a whole human post-mortem brain using the linear relaxometry model across 15 time-points comprised of one unfixed, in-situ MRI scan and 14 ex-vivo MRI scans at different stages of the fixation process (days 1-93).

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