To investigate APT-CEST feasibility as pH-sensitive contrast, a multislice CEST EPI sequence was evaluated. The proposed sequence allows continuous saturation during EPI measurement, leaving sufficient time to capture robust CEST data by multiple repetitions. The saturation scheme was optimized in a phantom study and with healthy volunteers. With the availability of 3D CEST data a subsequent registration of APT-CEST contrast images to 31P-MRSI can be achieved for evaluating pH-related changes in APT-CEST contrast. This is demonstrated in a study of a patient with glioblastoma.
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