For Chemical Exchange Saturation Transfer (CEST) imaging to be adopted as a routine clinical sequence, its spatial coverage and acquisition speed need ideally to be comparable to the current anatomical MRI sequences. To the best of our knowledge, whole-brain CEST imaging has only been demonstrated with 3D EPI readout, which, however, is vulnerable to susceptibility artifacts. Here, we propose a novel whole-brain isotropic-resolution CEST sequence utilizing the fast SPACE readout. The SPACE CEST sequence enables whole-brain 2.79mm isotropic CEST imaging in 5min without susceptibility artifacts, and should facilitate the translation of CEST MRI as a clinical routine sequence.
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