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Abstract #5027

Effect of Caffeine on Blood-Brain Barrier Water Permeability Measured with Intrinsic Diffusivity Encoding of Arterial Labeled Spins (IDEALS)

Kenneth Wengler1, Kwan Chen2, Mark E Schweitzer2, and Xiang He2

1Biomedical Engineering, Stony Brook University, Stony Brook, NY, United States, 2Radiology, Stony Brook University, Stony Brook, NY, United States

Caffeine is a commonly used neurostimulator that also produces cerebral vasoconstriction by antagonizing adenosine receptors. Previous studies demonstrate that acute caffeine intake leads to significant cerebral blood flow (CBF) reduction but have not investigated the effect on blood-brain barrier (BBB) water permeability. Here we provide an initial investigation into the effect of caffeine on BBB water permeability parameters, water extraction fraction (Ew) and permeability surface area product (PSw), using the recently developed Intrinsic Diffusivity Encoding of Arterial Labeled Spins (IDEALS). Significant reductions in CBF, Ew, and PSw were observed after administration of 200 mg caffeine.

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