Abstract #0019

Multi-organ comparison of flow-based Arterial Spin Labeling techniques: brain and kidney perfusion imaging without transit time artefacts

Suzanne L. Franklin^1,2,3, Isabell K. Bones², Anita A. Harteveld², Lydiane Hirschler¹, Marijn van Stralen², Anneloes de Boer², Hans Hoogduin², Matthias J.P. van Osch^1,3, Sophie Schmid^1,3, and Clemens Bos²

¹C.J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, ²Center for Image Sciences, University Medical Center Utrecht, Utrecht, Netherlands, ³Leiden Institute for Brain and Cognition, Leiden University, Leiden, Netherlands

Different flow-based arterial spin labeling (ASL)-techniques were proposed in recent years. In this multi-organ study four flow-based ASL-techniques were compared, with pCASL in brain, and with both pCASL and FAIR in kidney. ASL-techniques were compared based on temporal-SNR, sensitivity to perfusion changes (in brain) and robustness to respiratory motion (in kidney). In brain, Velocity-Selective Inversion showed superior temporal-SNR and sensitivity to perfusion changes. In kidney, flow-based ASL-techniques showed decreased temporal-SNR compared to FAIR, although their settings can be improved to increase robustness to B₁-inhomogeneity. All ASL-techniques were relatively robust to respiratory motion, showing potential for free-breathing kidney-ASL at 3T.

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