Diagnosis and staging in pediatric malignancies today involves different imaging procedures, from conventional x-ray over ultrasound to MR-, CT- and PET-imaging. We evaluated as if MRI can be used as a comprehensive one-stop shop for diagnosis, staging and biopsy in pediatric malignancies. As a result, when comparing the different imaging modalities, differences between MRI and CT were seen regarding the higher number of small lung lesions detected (<3mm) on CT. Comparable results were seen for abdominal tumors, Hodgkin- and Non-Hodgkin Lymphoma. In Ewing sarcoma MRI showed advantages compared with PET imaging regarding detection of skip lesions and bone marrow metastases.