Abstract #0083

In vivo evaluation of white matter abnormalities in children with DMD using diffusion MRI

Jitender Saini¹, Veeramani Preethish Kumar², Apurva Shah³, Manoj Kumar⁴, Madhura Ingalhalikar⁵, and Nalini Atchayaram ²

¹Nueroimaging and Interventional Radiology, National Institute of Mental Health and, Bangalore, India, ²Neurology, National Institute of Mental Health and, Bangalore, India, ³3Symbiosis Centre for Medical Image Analysis, Symbiosis International University, Pune, India, ⁴Neuroimaging and Interventional Radiology, National Institute of Mental Health and, Bangalore, India, ⁵Symbiosis Centre for Medical Image Analysis, Symbiosis International University, Pune, India

Duchenne muscular dystrophy (DMD), a genetically inherited X-linked neuromuscular disorder characterised by progressive muscle weakness and significant non-motor manifestations like poor IQ, and neuropsychiatric illnesses. In this study, we evaluate white matter (WM) abnormalities in DMD patients using diffusion tensor imaging (DTI). We observed widespread WM changes in DMD patients and the presence of distal mutation was associated with poor clinical and neuropsychological profile with severe and spatially more WM abnormalities.

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