Multimodal imaging for characterization of pancreatic tumour cellularity and metabolism has potential to guide treatment. Murine orthotopically transplanted tumours were imaged with DWI, 13C-pyruvate CSI, and 18F-FDG PET, and endogenous tumours with DWI and CSI. Transplanted epithelial and mesenchymal tumours had similar cellularity, shown by ADC, but different metabolism, with higher mesenchymal AUC ratios and SUV. Compared with other endogenous tumour growth patterns, classical ductal had lower tumour cellularity (higher ADC), while solid had higher and more-variable AUC ratios. The combination of these methods can characterize tumour metabolism, including correcting for tumour cellularity, better than CSI alone.