Abstract #0172

Developing imidazoles for performing functional MRI of kidneys

Shaowei Bo¹, KowsalyaDevi Pavuluri¹, Yunkou Wu², Farzad Sedaghat¹, Martin G. Pomper³, Max Kates⁴, and Michael T. McMahon⁵

¹The Russell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Department of Psychiatry, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁴Department of Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁵The Russell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, The Johns Hopkins University School of Medicine, F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

Urinary tract obstructions (UTOs) are blockages that inhibit the flow of urine through its normal path, which can lead to kidney injury and infection. Chemical exchange saturation transfer (CEST) MRI is a fast, noninvasive molecular MRI technique which has shown promise for clinical applications. In this study, we designed and tested a series of imidazoles as CEST MRI contrast agents and tested these for performing functional kidney imaging on a UTO mouse model. The results demonstrate that CEST MRI can facilitate early detection of loss in kidney function.

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