Inhomogeneous magnetization transfer (ihMT) is a myelin sensitive MRI technique that provides access to multiple contrast regimes by tuning the amount of dipolar relaxation time (T1D) weighting of the sequence. This opens new perspectives to characterize the sensitivity and specificity of ihMT for myelin in a pathological context. In this study, multiple T1D-weighting ihMT imaging was investigated in the cuprizone mouse model. IhMT signals compared to myelin imaging with fluorescence microscopy demonstrate that ihMT techniques that are weighted towards long T1D values are more specifically related to myelin content during the demyelinating/remyelinating phases of the cuprizone model.
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