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Abstract #0190

Age-dependent variation in CEST signal at low B1 may reflect decline of lipids in older brain tissue

Abigail Cember1,2, Puneet Bagga1, Hari Hariharan1, and Ravinder Reddy1
1Center for Magnetic Resonance and Optical Imaging, University of Pennsylvania, Philadelphia, PA, United States, 2Graduate Group in Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA, United States

In investigating the problem of CEST correction methods for low saturation B1, we observed differences in the behavior of the CEST asymmetry signal as a function of age. We believe this incidental observation to be a manifestation of the low saturation power induced NOE reported in other literature. In this case, we hypothesize that the physiological phenomenon underlying the pattern we observe is a decrease in myelin or other lipids in the aging brain. Our T1 maps corroborate literature collected at lower field strength that T1 values increase with age; however, this appears to be an independent, if related, phenomenon.

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