Abstract #0194

Effects of Arterial Stiffness on Cerebral White Matter Integrity in the Elderly

Koji Kamagata¹, Christina Andica¹, Kazunori Shimada², Hideyoshi Kaga³, Yuki Someya^3,4, Yuya Saito^1,5, Toshiaki Akashi¹, Akihiko Wada¹, Yoshifumi Tamura^3,4, Ryuzo Kawamori^3,4, Hirotaka Watada³, Hiroyuki Daida², and Shigeki Aoki¹

¹Department of Radiology, Juntendo University, Tokyo, Japan, ²Department of Cardiovascular Medicine, Juntendo University, Tokyo, Japan, ³Department of Metabolism & Endocrinology, Juntendo University, Tokyo, Japan, ⁴Sportology Center, Juntendo University, Tokyo, Japan, ⁵Department of Radiological Sciences, Tokyo Metropolitan University, Tokyo, Japan

Arterial stiffness has been shown to be associated with structural and functional abnormalities in the brain; however, white matter pathology related to arterial stiffness is poorly understood. In this study, we used white matter (WM) sensitive techniques (diffusion tensor imaging, neurite orientation dispersion and density imaging, free-water imaging, and magnetization transfer-saturation imaging) to better understand the impact of arterial stiffness on the WM microstructure in healthy elderly individuals. Our results suggest that arterial stiffness largely affects the content of cerebral myelin, as reflected by the myelin volume fraction.

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