Abstract #0201

Introducing Substantia Nigra Iron Content and Neuromelanin Overlap to Distinguish Parkinson’s Patients from Healthy Controls

Naying He¹, Kiarash Ghassaban^2,3, Pei Huang⁴, Zenghui Cheng¹, Yan Li¹, Mojtaba Jokar⁵, Sean K. Sethi^2,5, Weibo Chen⁶, Shengdi Chen⁴, Fuhua Yan¹, and Ewart Mark Haacke^1,2,5

¹Radiology, Ruijin Hospital, Shanghai Jiaotong Univ. School of Medicine, Shanghai, China, Shanghai, China, ²Department of Radiology, Wayne State University, Detroit, MI, United States, ³Department of Biomedical Engineering, Wayne State University, Detroit, MI, United States, ⁴Department of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, ⁵Magnetic Resonance Innovations, Inc., Bingham Farms, Bingham Farms, MI, United States, ⁶Philips Healthcare, Shanghai, China

A total of 40 Parkinson’s disease (PD) patients and 40 age- and sex-matched healthy controls (HC) were scanned using a single 3D gradient echo magnetization transfer sequence to measure neuromelanin and iron content, and the overlap between them. These measures showed reliable results indicative of powerful diagnostic biomarkers to differentiate PD patients from HCs. An increase in iron content was seen in the substantia nigra for the PD patients while the neuromelanin volume decreased. The best predictor, however, was found to be the combination of neuromelanin volume and its overlap with iron-containing substantia nigra which yielded an AUC of 98%.

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