Abstract #0215

Fast 3D High-Resolution Metabolic Imaging in Alzheimer's Disease using SPICE

Jialin Hu¹, Miao Zhang², Rong Guo^3,4, Yudu Li^3,4, Wanqing Sun¹, Danni Wang¹, Hui Huang¹, Yibo Zhao^3,4, Ziyu Meng^1,3, Biao Li², Jun Liu⁵, Binyin Li⁵, Jie Luo¹, Zhi-Pei Liang^3,4, and Yao Li¹

¹Institute for Medical Imaging Technology, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, ²Department of Nuclear Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, ³Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ⁴Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ⁵Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

As a progressive neurodegenerative disease, early diagnosis of Alzheimer’s disease (AD) is important but remains difficult. MRSI is a useful tool for detecting neurometabolic alterations in AD, but most studies were limited by using single-slice or single-voxel techniques with low spatial resolution and long data acquisition time. In this study, we performed 3D MRSI of AD patients at a nominal spatial resolution of 2.0 × 3.0 × 3.0 mm³ in a 7-min scan using a new technique called SPICE (SPectroscopic Imaging by exploiting spatiospectral CorrElation). Our experimental results showed noticeable neurometabolic changes in AD patients.

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