Abstract #0221

Deciphering transcriptomic basis of the human brain structural connectome in the 3rd trimester

Chenying Zhao^1,2, Gabriel Santpere³, David Andrijevic³, Minhui Ouyang¹, Nenad Sestan³, and Hao Huang^1,4

¹Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, United States, ²Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, United States, ³Department of Neuroscience and Kavli Institute for Neuroscience, Yale School of Medicine, New Haven, CT, United States, ⁴Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States

Dramatic development of brain connectome takes place during the 3^rd trimester, mediated by transcriptome. Transcriptome is complete set of gene-expressed mRNAs and is heterogeneous across brain regions and dynamic throughout development. The transcriptomic basis of structural connectome in this critical developmental stage is unknown. In this study, we identified transcription genes most significantly correlated to nodal efficiency and degree centrality of macroscale structural connectome based on diffusion MRI of 77 preterm brains and over 60,000 quantified transcriptomes. These identified transcription genes such as MYRF regulating oligodendrocyte differentiation and myelination may shed light into the transcriptomic basis of structural connectome development.

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