Abstract #0232

Emergence of distinct structural reorganization patterns in children as a result of temporal lobe epilepsy surgery – beyond voxel-based analysis

Luis Miguel Lacerda¹, Pedro Luque Laguna^2,3, Flavio Dell'acqua^2,3, and Chris Clark¹

¹Developmental Imaging and Biophysics Section, Institute of Child Health, University College London, London, United Kingdom, ²Forensic & Neurodevelopmental Sciences, King's College London, London, United Kingdom, ³Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom

We compared Tract-based Spatial Statistics (TBSS) with a recent method which relies on non-statistical parametric mapping in a tractography derived anatomical framework – tract-based cluster analysis (TBCA) - to explore the effect of surgery in Temporal Lobe Epilepsy. In particular, we investigated differences in fractional anisotropy (FA) as an effect of surgery, and if those changes depended on operated hemisphere. We found the same patterns of increased FA on the corona radiata and decreased FA in tracts traversing the temporal lobe with TBSS, whilst TBCA allowed for an increase in anatomical specificity when interpreting differences in this group.

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