Abstract #0237

Feasibility of oscillating and pulsed gradient diffusion MRI to assess neonatal hypoxia-ischemia on clinical system

Fusheng Gao¹, Xiaoxia Shen¹, Hongxi Zhang¹, Yi Zhang², Xiaolu Ma¹, Jiangyang Zhang³, and Dan Wu²

¹Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China, ²Key Laboratory for Biomedical Engineering of Ministry of Education, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China, ³Department of Radiology, New York University School of Medicine, New York, NY, United States

Despite the success of diffusion time (t_d) dependent diffusion MRI in simulation and preclinical studies, clinical applications of the technique are challenged by difficulties in accessing short t_d, limited primarily by the clinical gradient system. This study demonstrated the feasibility of t_d-dependent dMRI using oscillating and pulsed gradients on a 3T clinical system to investigate neonatal hypoxic-ischemic encephalopathy (HIE). Results demonstrated that the t_d-dependency (ΔMD) increased in the deep gray matter of infants during the first year. In HIE patients, ΔMD increased in the basal ganglia of the severe and moderate HIE, as well as in the penumbra of lesions.

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