White matter (WM) tracts organization in 42 polymicrogyria (PMG) and 8 lissencephaly (LIS) patients were characterized using the tissue-specific Constrained Spherical Deconvolution modelling technique. Structural appearance of 9 major WM tracts were judged using fiber orientation distribution based direction-encoded color maps and probabilistic algorithm based tractography reconstructions. More abnormal-appearing WM tracts were identified in LIS compared to PMG. Degrees of superior longitudinal fasciculus and cingulum abnormalities were associated with PMG distribution and severity. Thickened superior fronto-occipital fasciculus was demonstrated in three patients. Patterns of WM tracts involvement were related to PMG and LIS distribution and subgroups.