Abstract #0275

Utilising preclinical 23Na MRI to probe the ionic microenvironment of breast cancer: developing novel diagnostics to probe treatment efficacy.

Andrew D James^1,2, Theresa K Leslie^1,2, Marie-Christine BD Labarthe³, Michaela Nelson¹, Frank Riemer⁴, Gabrielle Baxter⁵, Joshua D Kaggie⁵, Fiona J Gilbert⁵, William Brackenbury^1,2, and Aneurin J Kennerley^2,3

¹Biology, University of York, York, United Kingdom, ²York Biomedical Research Institute, University of York, York, United Kingdom, ³Chemistry, University of York, York, United Kingdom, ⁴MMIV, Haukeland University Hospital, Bergen, Norway, ⁵Department of Radiology, University of Cambridge, Cambridge, United Kingdom

Here we applied ²³Na MRI, as part of a multiparametric imaging approach to measure ionic sodium concentration ([Na⁺]) levels in a longitudinal in-vivo mouse model of breast cancer. We investigated tumour [Na⁺] in response to neoadjuvant chemotherapy and ion channel inhibitors as a novel therapeutic means of reducing metastasis. Results show that [Na⁺] is decreased in tumour-bearing mice receiving standard chemotherapy. Data suggest that elevated tumour [Na⁺] in breast cancer may represent a potential imaging biomarker for malignancy and response to chemotherapy.

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