Abstract #0282

Magnetization Transfer and Chemical Exchange Saturation Transfer in Glioblastoma at 1.5T: Comparison of Early and Late Tumor Progression

Rachel W Chan¹, Sten Myrehaug², Greg J Stanisz^1,3,4, James Stewart², Mark Ruschin², Arjun Sahgal^2,3, and Angus Z Lau^1,3

¹Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, ²Department of Radiation Oncology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada, ³Medical Biophysics, University of Toronto, Toronto, ON, Canada, ⁴Department of Neurosurgery and Pediatric Neurosurgery, Medical University, Lublin, Poland

This study aims to quantify the MT and CEST parameters in glioblastoma at 1.5T over four time points of chemoradiation. Previous approaches to quantify the MT/CEST signal in terms of response to treatment were at higher field strengths. Additionally, we analyzed different subregions within the clinical target volume and gross tumor volume, generated by thresholding based on the T₁-weighted, FLAIR and DWI scans, for comparing the MT/CEST parameters between the early and late tumor progression. Results indicated that MT/CEST at 1.5T can be used for monitoring therapy and that the results depend on the specific tumor region analyzed.

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