Abstract #0321

Proton-density fat fraction-derived R2* liver iron concentration – an exploratory study of Revita-2 phase II trial data

Manil D Chouhan¹, Naomi Sakai¹, Francisco Torrealdea², Kelly White³, Juan Carlos Lopez Talavera³, Alan Bainbridge², and Stuart A Taylor¹

¹UCL Centre for Medical Imaging, University College London, London, United Kingdom, ²Department of Medical Physics, University College London Hospitals NHS Trust, London, United Kingdom, ³Fractyl Laboratories Inc., Lexington, MA, United States

R2* derived liver iron concentration (LIC) measurements from proton density fat fraction (PDFF) data obtained in patients with normal LIC levels may be useful. Here we present data from the Revita-2 trial demonstrating strong significant positive correlations between baseline liver fat fraction (FF) and LIC. Significant and stronger correlations between relative % change in liver FF and LIC in the treatment arms of the trial raise the possibility of treatment-related mechanistic effects on hepatic iron metabolism.

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