Functional single-voxel MRS (fMRS) was capable to sensitively detect metabolite responses to sensory stimulation, but suffered from large partial volume effects, that questioned the clinical utility of fMRS. Free-induction decay (FID)-MRSI promises to possess sufficient SNR to reach the sensitivity of SV-MRS and overcome its limitations by selective mapping the volume of interest with multiple voxels and thus, with higher spatial resolution, minimize the partial volume issue. Concentric-ring-trajectories (CRT)-based 3D FID-MRSI showed sufficient sensitivity and temporal stability to detect functional glutamate changes in the dominant sensorimotor region with expected most robust metabolite responses during finger tapping task.
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