Abstract #0403

Differentiation of IDH Mutant from IDH wild-type High-grade Gliomas using Combined Analysis of Diffusion and Perfusion MRI

Santosh Kumar Yadav¹, Sumei Wang², Shadi Asadollahi², MacLean Nasrallah³, Steven Brem⁴, Mohammad Haris¹, Suyash Mohan², and Sanjeev Chawla²

¹Research, Sidra Medicine, Doha, Qatar, ²Department of Radiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States, ³Department of Pathology and Lab Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States, ⁴Department of Neurosurgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States

Accurate identification of isocitrate dehydrogenase (IDH) mutant high-grade glioma is clinically important. We investigated the combined utility of diffusion (DTI) and perfusion (DSC-PWI) MR imaging in distinguishing IDH mutant from IDH wild-type high-grade gliomas. Treatment naïve patients (n=30) with IDH-mutant (n=14) and IDH-wild-type (n=16) high-grade gliomas were recruited. A classification model comprising of mean diffusivity, coefficient of planar anisotropy and maximum relative cerebral blood volume differentiated two genotypes of gliomas with an accuracy of 85%, a sensitivity of 87.2%, and a specificity of 81.5%. Combined analysis of DTI and DSC-PWI may be helpful in distinguishing IDH profiles of high-grade gliomas.

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